تفاعل #319161

معادلة التفاعل

product

2-[(1H-1,2,4-triazol-1yl)methyl]benzenesulfonamide

phenyl(4,6-dimethoxypyrimidin-2-yl)carbamate

DBU

→

subject compound

المردود 70.7%

N-[(4,6-Dimethoxypyrimidin-2-yl)aminocarbonyl]-2-[(1H-1,2,4-triazol-2-yl)methyl]benzenesulfonamide

المردود 70.7%

المذيبات

p-dioxane

water

ظروف التفاعل

المعالجة

1. 1
   ترشيحfiltered
2. 2
   ترشيحfiltered
3. 3
   غسيلThe residue was washed 2×10 ml water
4. 4
   أخرىsuction-dried 16 hours
5. 5
   أخرىtriturated with about 10 ml of warm ethyl acetate

الإجراء التجريبي

By the procedure of Example 4, 0.4 g of the product of Example 7 was reacted with 0.52 g of phenyl(4,6-dimethoxypyrimidin-2-yl)carbamate and 0.26 g of "DBU" in 10 ml of p-dioxane. After stirring at 25° C. for two hours, the resulting suspension was diluted with about 50 ml of water, and filtered; the resulting filtrate was acidified with concentrated hydrochloric acid to pH 4, then filtered. The residue was washed 2×10 ml water, suction-dried 16 hours, then triturated with about 10 ml of warm ethyl acetate to yield 0.5 g of the subject compound; m.p. 219°-220° C. IR(nujol): 1690 cm-1 (c=o); NMR(CDCl3): ppm 3.9(S, 6H, OCH3); 5.8(S, 1H, py H); 6.0(S, 2H, CH2); 7.9 and 8.2(2S, 2H, tri 2H); 7.1-7.6(m, 4H, Ar+NH); 8.15(m, 1H, Ar).

المصدر