تفاعل #318705

معادلة التفاعل

(3-amino-1H-pyrazol-4-yl)-2-furanylmethanone

malonaldehyde bis(dimethyl acetal)

acetic acid

→

2-furanylpyrazolo[1,5-a]pyrimidin-3-yl-methanone

ظروف التفاعل

المعالجة

1. 1
   أخرىprepared
2. 2
   درجة الحرارةwas heated
3. 3
   درجة الحرارةat reflux for 8 hours
4. 4
   أخرىThe solvent was evaporated

الإجراء التجريبي

A mixture of 7.08 g of (3-amino-1H-pyrazol-4-yl)-2-furanylmethanone (prepared as described in U.S. Pat. appliction Ser. No. 612,811, filed May 24, 1984), 8.20 g of malonaldehyde bis(dimethyl acetal) and 100 ml of glacial acetic acid was heated at reflux for 8 hours. The solvent was evaporated and the solid was worked up as described in Example 50 to give 4.92 g of 2-furanylpyrazolo[1,5-a]pyrimidin-3-yl-methanone, mp 222°-224° C.

المصدر