تفاعل #318660

ord-5362125a959241d1a1e26f345bbf0945

معادلة التفاعل

Cc1cc(O)cc(C)c1CC(NC(=O)OC(C)(C)C)C(=O)N[C@H](C)C(=O)NC1CCc2ccccc21
title compound
Cc1cc(O)cc(C)c1CC(NC(=O)OC(C)(C)C)C(=O)N[C@H](C)C(=O)NC1CCc2ccccc21
N-[(1,1-dimethylethoxy)carbonyl]-2,6-dimethyl-DL-tyrosyl-N-(2,3-dihydro-1H-inden-1-yl)-D-alaninamide
Cl
HCl
→
Cc1cc(O)cc(C)c1CC(N)C(=O)N[C@H](C)C(=O)NC1CCc2ccccc21.Cl
2,6-dimethyl-DL-tyrosyl-N-(2,3-dihydro-1H-inden-1-yl)-D-alaninamide, monohydrochloride

المتفاعلات

Cc1cc(O)cc(C)c1CC(NC(=O)OC(C)(C)C)C(=O)N[C@H](C)C(=O)NC1CCc2ccccc21
title compound
Cc1cc(O)cc(C)c1CC(NC(=O)OC(C)(C)C)C(=O)N[C@H](C)C(=O)NC1CCc2ccccc21
N-[(1,1-dimethylethoxy)carbonyl]-2,6-dimethyl-DL-tyrosyl-N-(2,3-dihydro-1H-inden-1-yl)-D-alaninamide
Cl
HCl

الكواشف

لا شيء

ظروف التفاعل

الظروف التفصيلية
See reaction.notes.procedure_details.

الإجراء التجريبي

The title compound of Example 18 was deblocked and converted to its HCl salt by the method of Example 6.

المصدر

DOI: 10.6084/m9.figshare.5104873.v1براءة الاختراع: US04847241uspto-grants-1989_07