تفاعل #318587

معادلة التفاعل

sulfonamide

4-cyclopropylcarbonyl-1-methyl-5-pyrazolesulfonamide

phenylcarbamate

4,6-dimethoxy-2-aminopyrimidine

diazobicycloundecane

→

desired compound

4-(Cyclopropylcarbonyl)-N-[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-1-methyl-1H-pyrazole-5-sulfonamide

المذيبات

acetonitrile

ظروف التفاعل

المعالجة

1. 1
   ترشيحAcidification of the reaction mixture and filtration of the resulting solids

الإجراء التجريبي

To a stirring mixture of the sulfonamide from Example 2 (175 mg, 0.76 mmol) and the phenylcarbamate of 4,6-dimethoxy-2-aminopyrimidine (210 mg, 0.76 mmol) in 3 ml of acetonitrile was added diazobicycloundecane (116 mg, 0.76 mmol). The solution was stirred for approximately 10 minutes. Acidification of the reaction mixture and filtration of the resulting solids afforded 300 mg of the desired compound m.p. 189°-192° C. NMR (200 MHz, CDCl3) 1.0 (m, 2H), 1.1 (m, 2H), 2.4 (m, 1H), 4.0 (s, 6H), 4.35 (s, 1H), 5.80 (s, 1H), 7.4 (br. s, 1H), 8.05 (s, 1H), 12.9 (s, 1H).

المصدر