تفاعل #318404

معادلة التفاعل

4-phenylcyclohexanone

acetic anhydride

→

2-acetyl-4-phenylcyclohexanone

المردود 71.3%

المذيبات

ammonium acetate

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةcooled
2. 2
   workup.ADDITIONwas dropwise added to the complex
3. 3
   workup.STIRRINGby stirring at 80° C for 1.5 hours
4. 4
   استخلاصThe reaction mixture was extracted with ether
5. 5
   أخرىthe extract was purified

الإجراء التجريبي

40% Boron trifluoride-acetic acid complex, 5.5 g, was ice-cooled and a mixture of 2 g of 4-phenylcyclohexanone and 2.35 g of acetic anhydride was dropwise added to the complex. After stirring for 30 minutes under ice cooling and at room temperature for 4 hours, 10 ml of saturated ammonium acetate aqueous solution was added to the mixture followed by stirring at 80° C for 1.5 hours. The reaction mixture was extracted with ether and the extract was purified to obtain 1.77 g of 2-acetyl-4-phenylcyclohexanone.

المصدر