تفاعل #318297

معادلة التفاعل

4-{2-[4-(2-ethoxyethyl)-2-methylphenoxy]ethylamino}thieno[2,3-d]pyrimidine

oxalic acid

→

title compound

المردود 87.2%

4-{2-[4-(2-ethoxyethyl)-2-methylphenoxy]ethylamino}thieno[2,3-d]pyrimidine oxalate

المردود 87.2%

المذيبات

acetone

acetone

ظروف التفاعل

المعالجة

1. 1
   workup.ADDITIONwas added
2. 2
   أخرىReaction
3. 3
   أخرىseparated
4. 4
   درجة الحرارةwhilst heating
5. 5
   درجة الحرارةThe mixture was cooled
6. 6
   ترشيحthe crystals were collected by filtration
7. 7
   أخرىrecrystallized from acetone

الإجراء التجريبي

3.6 g of 4-{2-[4-(2-ethoxyethyl)-2-methylphenoxy]ethylamino}thieno[2,3-d]pyrimidine were dissolved in 30 ml of acetone, and 0.9 g of anhydrous oxalic acid dissolved in 30 ml of acetone was added thereto. Reaction occurred at once, and crystals separated. The mixture was stirred for a further 30 minutes whilst heating. The mixture was cooled, and the crystals were collected by filtration and recrystallized from acetone to give 3.9 g of the title compound as colorless columnar crystals melting at 151°-152° C.

المصدر