تفاعل #317298

معادلة التفاعل

N-(2,6-dimethylphenyl)-2-piperazinylacetamide

N-(4-methoxyphenyl)-2-oxiran-2-ylacetamide

triethylamine

→

4-(4-{[N-(2,6-dimethylphenyl)carbamoyl]methyl}-piperazinyl)-3-hydroxy-N-(4-methoxyphenyl)butanamide

المذيبات

ethanol

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةto reflux for 18 hours
2. 2
   أخرىSolvent was removed from the reaction mixture under reduced pressure
3. 3
   أخرىthe residue purified by column chromatography on silica gel
4. 4
   غسيلeluting with 5% MeOH/dichloromethane

الإجراء التجريبي

To a solution of crude N-(4-methoxyphenyl)-2-oxiran-2-ylacetamide (10) in ethanol (2.5 mL) was added triethylamine (0.5 mL), followed by N-(2,6-dimethylphenyl)-2-piperazinylacetamide, a compound of formula (4) (150 mg), and the mixture was heated to reflux for 18 hours. Solvent was removed from the reaction mixture under reduced pressure, and the residue purified by column chromatography on silica gel, eluting with 5% MeOH/dichloromethane, to give 4-(4-{[N-(2,6-dimethylphenyl)carbamoyl]methyl}-piperazinyl)-3-hydroxy-N-(4-methoxyphenyl)butanamide, a compound of Formula I as an off-white solid.

المصدر