تفاعل #316550

معادلة التفاعل

nitrile

1-ethyl-3-[7-(5-methyl-2H-[1,2,4]triazol-3-yl)-imidazo[1,2-a]pyridin-2-yl]-urea

trifluoroacetamide

dimethylaminoacrolein

→

pyrimidine

1-[7-(1,5-dimethyl-1H-[1,2,4]triazol-3-yl)-imidazo[1,2-a]pyridin-2-yl]-3-ethyl-urea

المذيبات

ethanol

ظروف التفاعل

المعالجة

1. 1
   أخرىThe reaction was then evaporated in vacuo
2. 2
   أخرىthe residue was purified by silica gel chromatography (gradient elution: 0-20% ethyl acetate/dichloromethane)

الإجراء التجريبي

A mixture of nitrile 4 (0.500 g, 1.7 mmol), 0.50 g trifluoroacetamide and 0.25 g dimethylaminoacrolein in 5 mL ethanol was heated to 125° C. for 2 h by microwave irradiation (CEM, 300 watt). The reaction was then evaporated in vacuo and the residue was purified by silica gel chromatography (gradient elution: 0-20% ethyl acetate/dichloromethane) to give pyrimidine 5.

المصدر