تفاعل #316225

معادلة التفاعل

hydrochloric acid

2-Amino-pyridine-3-carbaldehyde

1-bromo-3,3-dimethyl-butan-2-one

sodium hydroxide

→

2-tert-butyl-[1,8]naphthyridin-3-ol

المردود 24.0%

ظروف التفاعل

المعالجة

1. 1
   أخرىthe suspension was hermtically sealed and, in this state
2. 2
   ترشيحthe resultant precipitate was then collected by filtration
3. 3
   غسيلwas washed with water and chloroform
4. 4
   أخرىThe powder as the residue was dried under the reduced pressure

الإجراء التجريبي

2-Amino-pyridine-3-carbaldehyde (100 mg) and 1-bromo-3,3-dimethyl-butan-2-one (147 mg) were suspended in a 5 N aqueous sodium hydroxide solution (0.6 ml), and the suspension was hermtically sealed and, in this state, was allowed to stand for 3 days. The reaction solution was neutralized with 10% hydrochloric acid, and the resultant precipitate was then collected by filtration and was washed with water and chloroform. The powder as the residue was dried under the reduced pressure to give 2-tert-butyl-[1,8]naphthyridin-3-ol (40 mg, yield 24%).

المصدر