تفاعل #314457

معادلة التفاعل

6-fluoroindol

4-piperidone monohydrate hydrochloride

→

6-fluoro-3-piperidin-4-yl-1H-indole

المردود 51.0%

ظروف التفاعل

المعالجة

1. 1
   أخرىThis compound was prepared
2. 2
   أخرىfor 1 hour

الإجراء التجريبي

This compound was prepared following the procedure described in Example 1 (steps A and B) starting with 1 g (7.4 mmol) of 6-fluoroindol and 2.84 g (18.5 mmol) of 4-piperidone monohydrate hydrochloride. In this case, the hydrogenation step took place for 1 hour at 2 bar and the catalyst used was platinum (IV) oxide. 0.640 g (51% yield) of 6-fluoro-3-piperidin-4-yl-1H-indole were obtained.

المصدر