تفاعل #314448

معادلة التفاعل

indole

potassium hydroxide

4-piperidone monohydrate hydrochloride

→

final product

3-(1,2,3,6-tetrahydro-pyridin-4-yl)-1H-indole

المذيبات

methanol

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةthe mixture was heated
2. 2
   درجة الحرارةto reflux for 5 h
3. 3
   أخرىPotassium chloride precipitated
4. 4
   ترشيحit was filtered off
5. 5
   تركيزThe liquid phase was concentrated until only one third of the liquid
6. 6
   أخرىThe solid formed during the concentration of the liquid phase
7. 7
   ترشيحwas filtered
8. 8
   غسيلwashed thoroughly with ethanol

الإجراء التجريبي

30 g (0.26 mol) of indole were dissolved in a solution of potassium hydroxide (77.6 g, 1.38 mol) in methanol (692 ml). 4-piperidone monohydrate hydrochloride (102.3 g, 0.66 mol) was added in one portion and the mixture was heated to reflux for 5 h. Potassium chloride precipitated upon cooling at room temperature and it was filtered off. The liquid phase was concentrated until only one third of the liquid remained in the round-bottom flask. The solid formed during the concentration of the liquid phase was filtered and washed thoroughly with ethanol and, finally, with ethyl ether. 31.9 g (63% of yield) of the final product were obtained.

المصدر