تفاعل #314387

معادلة التفاعل

Sodium dodecylsulfate

N-isopropylacrylamide

acrylic acid

methylenebisacrylamide

potassium persulfate

→

N-isopropylacrylamide acrylic acid

المذيبات

water

ظروف التفاعل

المعالجة

1. 1
   workup.WAITfollowed by 4 hours
2. 2
   workup.STIRRINGof stirring
3. 3
   أخرىThe obtained particles (precursor of Example 3) are purified in water by means of dialysis
4. 4
   workup.ADDITIONThese particles (700 mg) are then dispersed in tetrahydrofuran (30 ml)/dimethylformamide (10 ml)
5. 5
   workup.ADDITIONa tetrahydrofuran (10 ml)/dimethylformamide (50 ml) solution of dicyclohexylcarbodiimide (800 mg), hydroxybenzotriazole (500 mg), and 2,2′-(ethylenedioxy)bis(ethylamine) (1.14 g) is added at room temperature
6. 6
   workup.WAITfollowed by an overnight
7. 7
   workup.STIRRINGstirring
8. 8
   أخرىThe particles are then dialyzed
9. 9
   workup.ADDITIONThey are dispersed in methanol (70 ml), to which 1.2 g of the chemical compound of Synthetic example 1
10. 10
    workup.ADDITIONis added
11. 11
    workup.WAITfollowed by a 6 hour
12. 12
    workup.STIRRINGstirring at room temperature
13. 13
    درجة الحرارةthis mixture is cooled in an ice bath
14. 14
    workup.ADDITION3 g of sodium cyanotrihydroborate is added
15. 15
    workup.WAITfollowed by an overnight
16. 16
    workup.STIRRINGstirring at room temperature
17. 17
    أخرىThe obtained particles are dialyzed in water

الإجراء التجريبي

Sodium dodecylsulfate (20 mg), N-isopropylacrylamide (2.4 g), acrylic acid (382 mg), and methylenebisacrylamide (121 mg) are dissolved in 200 ml of water, and, after a 30 minute stirring at 70° C. in a nitrogen atmosphere, a polymerization initiator (potassium persulfate 9.2 mg) is added, followed by 4 hours of stirring. The obtained particles (precursor of Example 3) are purified in water by means of dialysis, and then lyophilized. These particles (700 mg) are then dispersed in tetrahydrofuran (30 ml)/dimethylformamide (10 ml), and a tetrahydrofuran (10 ml)/dimethylformamide (50 ml) solution of dicyclohexylcarbodiimide (800 mg), hydroxybenzotriazole (500 mg), and 2,2′-(ethylenedioxy)bis(ethylamine) (1.14 g) is added at room temperature, followed by an overnight stirring. The particles are then dialyzed and lyophilized. They are dispersed in methanol (70 ml), to which 1.2 g of the chemical compound of Synthetic example 1 is added, followed by a 6 hour stirring at room temperature; this mixture is cooled in an ice bath, and 3 g of sodium cyanotrihydroborate is added, followed by an overnight stirring at room temperature. The obtained particles are dialyzed in water to obtain the target N-isopropylacrylamide/acrylic acid copolymer particles (650 mg) containing phosphorylcholine groups.

المصدر