تفاعل #314214

معادلة التفاعل

1-(6-bromo-pyridin-2-ylmethyl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid methoxy-methyl-amide

3,4-dichlorophenylmagnesium bromide

→

1-(6-Bromo-pyridin-2-ylmethyl)-3-(3,4-dichloro-benzoyl)-1H-quinolin-4-one

المذيبات

THF

ظروف التفاعل

الإجراء التجريبي

Experimental conditions analogous to those described for Step 6 of Example 60 from 90 mg (0.22 mmol) of 1-(6-bromo-pyridin-2-ylmethyl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid methoxy-methyl-amide in 1 mL THF and 0.98 mL 0.5M 3,4-dichlorophenylmagnesium bromide. Yield: 64 mg of a white solid. LC-MSD, m/z for C22H13BrCl2N2O2 [M+H]+=487.0, 489.0, 491.0; HPLC retention time: 2.9 min.

المصدر