تفاعل #312480

معادلة التفاعل

NaOH

phosphorus

dimethylformamide

7-(α,α,α-trifluoro-m-tolyl)pyrazolo[1,5-a]pyrimidine

→

7-(α,α,α-Trifluoro-m-tolyl)pyrazolo[1,5-a]pyrimidine-3-carboxaldehyde

ظروف التفاعل

المعالجة

1. 1
   workup.ADDITIONThe mixture is poured onto ice
2. 2
   أخرىThe precipitated solid is removed by filtration
3. 3
   أخرىrecrystallized from methylene chloride-hexane
4. 4
   أخرىto give the product, m.p. 196°-198° C.

الإجراء التجريبي

Seventy-five milliliters of dried dimethylformamide is cooled in an ice bath and 25 ml. of phosphorus osychloride is added dropwise with swirling. To this ice cold mixture is added 19.5 g. of 7-(α,α,α-trifluoro-m-tolyl)pyrazolo[1,5-a]pyrimidine in one portion and the reaction mixture is then heated on a steam bath for 1.5 hours. The mixture is poured onto ice and made basic (pH 10) with 10 N NaOH. The precipitated solid is removed by filtration and recrystallized from methylene chloride-hexane to give the product, m.p. 196°-198° C.

المصدر