تفاعل #312446

معادلة التفاعل

7-(α,α,α-trifluoro-m-tolyl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid

diborane

→

3-Methyl-7-(α,α,α-trifluoro-m-tolyl)pyrazolo[1,5-a]pyrimidine

المذيبات

tetrahydrofuran

tetrahydrofuran

ظروف التفاعل

المعالجة

1. 1
   workup.ADDITIONthe mixture is poured onto ice
2. 2
   استخلاصthe product extracted into dichloromethane
3. 3
   غسيلThe dichloromethane layer is washed with water
4. 4
   تجفيفdried (MgSO4)
5. 5
   أخرىthe solvent removed
6. 6
   أخرىto give the product of the example

الإجراء التجريبي

A solution of 0.01 mole of 7-(α,α,α-trifluoro-m-tolyl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid in tetrahydrofuran is added dropwise to a chilled (0° C.) solution of 0.02 mole of diborane in tetrahydrofuran. After standing overnight the mixture is poured onto ice and the product extracted into dichloromethane. The dichloromethane layer is washed with water, dried (MgSO4) and the solvent removed to give the product of the example.

المصدر