تفاعل #312442

معادلة التفاعل

4-(α,α,α-trifluoro-m-tolyl)imidazo[1,5-a]pyrimidine-8-carboxylic acid

diborane

→

8-Methyl-4-(α,α,α-trifluoro-m-tolyl)imidazo[1,5-a]pyrimidine

المذيبات

tetrahydrofuran

tetrahydrofuran

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةchilled in an ice bath
2. 2
   workup.ADDITIONThe mixture is poured onto ice
3. 3
   استخلاصextracted with methylene chloride
4. 4
   استخلاصThe methylene chloride extract
5. 5
   غسيلis washed with water
6. 6
   تجفيفdried (MgSO4)
7. 7
   أخرىThe solvent is removed under reduced pressure
8. 8
   أخرىto give the product of the example

الإجراء التجريبي

A solution of 0.010 mole of 4-(α,α,α-trifluoro-m-tolyl)imidazo[1,5-a]pyrimidine-8-carboxylic acid in tetrahydrofuran is added dropwise to a 0.02 molar solution of diborane in tetrahydrofuran chilled in an ice bath. The mixture is allowed to warm to room temperature and stand overnight. The mixture is poured onto ice and extracted with methylene chloride. The methylene chloride extract is washed with water and dried (MgSO4). The solvent is removed under reduced pressure to give the product of the example.

المصدر