تفاعل #312

معادلة التفاعل

CN1Cc2ccc(Cl)nc2O[C@

Cc1ncn(-c2ccc(N)cc2)

→

Cc1ncn(-c2ccc(Nc3ccc

المذيبات

COCCOC

ظروف التفاعل

الإجراء التجريبي

A solution of (R)-8-chloro-4-methyl-2-phenyl-2,3,4,5-tetrahydropyrido[3,2-f][1,4]oxazepine (5.00 mg, 0.02 mmol) and 4-(3-methyl-1H-1,2,4-triazol-1-yl)aniline (3.17 mg, 0.02 mmol) in DME (.5 mL) was added via a syringe to a capped microwave vial containing Pd2(dba)3 (0.833 mg, 0.91 µmol), 2-(DICYCLOHEXYLPHOSPHINO)BIPHENYL (0.638 mg, 1.82 µmol) and Cs2CO3 (8.89 mg, 0.03 mmol) under an argon atmosphere. The resulting mixture was heated to 100°C in a microwavwe apparatus for 1 h and analyzed by LCMS. No product.

المصدر