تفاعل #311667

معادلة التفاعل

phosphorous oxychloride

2,4-dihydroxy-6-methyl-pyrimidine

phosphorous oxychloride

diethylaniline

NaCl

NaOH

→

title compound

2,4-Dichloro-6-methyl-pyrimidine

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةAfter having been refluxed during 3 hours the reaction mixture
2. 2
   درجة الحرارةwas cooled
3. 3
   استخلاصextracted with ether
4. 4
   أخرىBy separation and evaporation of the ethereal extracts
5. 5
   أخرىthere was obtained a residue which
6. 6
   workup.DISTILLATIONwas distilled

الإجراء التجريبي

45 g (0.36 M) of 2,4-dihydroxy-6-methyl-pyrimidine have been treated with phosphorous oxychloride in the presence of diethylaniline. After having been refluxed during 3 hours the reaction mixture was cooled and the excess of phosphorous oxychloride was decomposed over ice, then the mixture was neutralized with NaOH, saturated with a NaCl solution and extracted with ether. By separation and evaporation of the ethereal extracts there was obtained a residue which was distilled to yield 57 g of the title compound at B.p. 99°/11 Torr.

المصدر