تفاعل #311496

معادلة التفاعل

NaOH

o-aminothiophenol

p-toluic acid

→

pure product

المردود 76.3%

4-(benzothiazol-2-yl) toluene

المردود 76.3%

المذيبات

water

ظروف التفاعل

المعالجة

1. 1
   ترشيحthe resulting crystals were filtered off, whereupon 220 g of 4-(benzothiazol-2-yl) toluene
2. 2
   أخرىwas obtained as crude crystals
3. 3
   أخرىRecrystallization from n-hexane

الإجراء التجريبي

125 g (1 mol) of o-aminothiophenol, 136 g (1 mol) of p-toluic acid and 600 g of polyphosphoric acid were admixed and stirred into nitrogen gas at 170°-200° C. for 4 hours. After the reaction mixture was cooled to 100° C., it was poured in 5 l of water. The mixture was adjusted to pH 5 with NaOH and the resulting crystals were filtered off, whereupon 220 g of 4-(benzothiazol-2-yl) toluene was obtained as crude crystals. Recrystallization from n-hexane gave 172 g of pure product as colorless prisms melting at 84°-85° C.

المصدر