تفاعل #311398

معادلة التفاعل

2-amino-4-dimethylamino-6-methoxypyrimidine

2-chlorobenzenesulfonylisocyanate

→

2-Chloro-N-[(4-dimethylamino-6-methoxypyrimidin-2-yl)-aminocarbonyl]benzenesulfonamide

المذيبات

acetonitrile

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةThe mixture was warmed to 40°
2. 2
   أخرىThe solid product named above was isolated by filtration
3. 3
   غسيلwashed with a small amount of cold ethyl ether

الإجراء التجريبي

To 700 ml of acetonitrile containing 25 g of 2-amino-4-dimethylamino-6-methoxypyrimidine at ambient temperature was added, dropwise, 32.5 g of 2-chlorobenzenesulfonylisocyanate. The mixture was warmed to 40° and then allowed to stir for five hours at ambient temperature. The solid product named above was isolated by filtration and washed with a small amount of cold ethyl ether. It melted at 224°-226°.

المصدر