تفاعل #310938

معادلة التفاعل

2-ethylmercapto-3-ethylbenzothiazolium p-toluenesulfonate

3-carboethoxymethylrhodanine

→

3-carboethoxymethyl-5-(3-ethylbenzothiazolylidene)rhodanine

المذيبات

triethylamine

ظروف التفاعل

المعالجة

1. 1
   workup.ADDITIONwas added dropwise to the solution over a 3 minute period
2. 2
   درجة الحرارةAfter cooling the reaction mixture
3. 3
   أخرىprecipitates
4. 4
   أخرىformed
5. 5
   ترشيحwere recovered by filtration
6. 6
   أخرىrecrystallized from a mixture of chloroform and ethanol

الإجراء التجريبي

To 30 ml of an ethanol solution of 13.0 g of the intermediate product obtained in Preparative Example 2, viz., 2-ethylmercapto-3-ethylbenzothiazolium p-toluenesulfonate, was added 4.4 g of 3-carboethoxymethylrhodanine, while stirring the mixture at room temperature (about 20° C.), 6.1 g of triethylamine was added dropwise to the solution over a 3 minute period, and thereafter the resultant mixture was refluxed for 10 minutes. After cooling the reaction mixture, precipitates formed were recovered by filtration and recrystallized from a mixture of chloroform and ethanol to provide 1.1 g of 3-carboethoxymethyl-5-(3-ethylbenzothiazolylidene)rhodanine (melting point 250° to 252° C.).

المصدر