تفاعل #310028

معادلة التفاعل

methyl 4-carboxymethyl-2-methoxy-benzoate

sulfuryl chloride

→

methyl 5-chloro-4-carboxymethyl-2-methoxy-benzoate

المذيبات

acetic acid

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةThe whole is refluxed for 6 hours
2. 2
   أخرىAfter evaporation of the solvent
3. 3
   أخرىthe reaction crude product
4. 4
   أخرىis purified on silica gel (petroleum ether/ethyl acetate

الإجراء التجريبي

To 300 mg of methyl 4-carboxymethyl-2-methoxy-benzoate from preparation 1 placed in 6 mL of acetic acid, are added 110 μL of sulfuryl chloride (1 equivalent). The whole is refluxed for 6 hours. After evaporation of the solvent, the reaction crude product is purified on silica gel (petroleum ether/ethyl acetate: 80/20 then 60/40) leading to 165 mg of the desired compound.

المصدر