تفاعل #309834

معادلة التفاعل

Piperidine

5-bromo-2-chloropyrimidine

triethylamine

→

title compound ( D32 )

5-Bromo-2-(1-piperidinyl)pyrimidine

المذيبات

toluene

ethyl acetate

ظروف التفاعل

المعالجة

1. 1
   غسيلwashed with 2N hydrochloric acid, brine
2. 2
   تجفيفdried (magnesium sulfate)
3. 3
   ترشيحThe organic layer was filtered
4. 4
   تركيزconcentrated in vacuo
5. 5
   أخرىthe resulting residue was purified by column chromatography
6. 6
   غسيلeluting with ethyl acetate

الإجراء التجريبي

Piperidine (5.1 ml, 51.6 mmol) was added to a stirred solution of 5-bromo-2-chloropyrimidine (5 g, 25.8 mmol) and triethylamine (9.0 ml, 64.5 mmol) in toluene (30 ml). After stirring at room temperature for 24 hours the reaction mixture was diluted with ethyl acetate and washed with 2N hydrochloric acid, brine and dried (magnesium sulfate). The organic layer was filtered, concentrated in vacuo and the resulting residue was purified by column chromatography eluting with ethyl acetate to afford the title compound (D32).

المصدر