تفاعل #309815

معادلة التفاعل

2-Aminoimidazole monosulfate

potassium carbonate

chloroethyl piperidine mono hydrochloride

→

oil

المردود 22.6%

1-(2-Piperidin-1-yl-ethyl)-1H-imidazol-2-ylamine

المردود 22.6%

المذيبات

DMF

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةbefore being cooled to room temperature
2. 2
   ترشيحfiltered
3. 3
   تركيزThe filtrate was concentrated
4. 4
   أخرىpurified by column chromatography (95:4.5:0.5 dichloromethane:methanol:aqueous ammonia)

الإجراء التجريبي

2-Aminoimidazole monosulfate (500 mg, 1.89 mmol) and potassium carbonate (580 mg, 4.16 mmol) were suspended in DMF (2 mL) and chloroethyl piperidine mono hydrochloride (766 mg, 4.16 mmol) was added. The reaction was heated at 100° C. for 2.5 hours before being cooled to room temperature and filtered. The filtrate was concentrated and purified by column chromatography (95:4.5:0.5 dichloromethane:methanol:aqueous ammonia) and the product was isolated as a brown oil (83 mg, 11%).

المصدر