تفاعل #307249

معادلة التفاعل

6-(4-Chlorophenyl)-N-cyclopropylpyrimidine-4,5-diamine

2-ethylnicotinoyl chloride

NaHCO3

→

N-[4-(4-Chlorophenyl)-6-cyclopropylaminopyrimidin-5-yl]-2-ethylnicotinamide

المذيبات

DCM

pyridine

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةthe reaction mixture was warmed to room temperature
2. 2
   أخرىthe organic phase was separated off
3. 3
   تركيزconcentrated under reduced pressure

الإجراء التجريبي

6-(4-Chlorophenyl)-N-cyclopropylpyrimidine-4,5-diamine (1.00 g, 3.83 mmol) was initially charged in a mixture of DCM (3.20 ml) and pyridine (0.93 ml) and cooled to 0° C. Solid 2-ethylnicotinoyl chloride (780 mg, 4.60 mmol) was added, and the reaction mixture was warmed to room temperature and stirred for another hour. After addition of semisaturated NaHCO3 solution, the organic phase was separated off and concentrated under reduced pressure.

المصدر