تفاعل #3058

معادلة التفاعل

cycloheptylamine

diisopropylethylamine

bromoacetyl bromide

→

solid

المردود 89.7%

Bromo-N-cycloheptyl acetamide

المردود 89.7%

المذيبات

methylene chloride

water

ظروف التفاعل

المعالجة

1. 1
   أخرىTo a -20° C.
2. 2
   workup.STIRRINGstirred for an additional 30 minutes
3. 3
   أخرىThe organic layer was separated
4. 4
   غسيلwashed with water (3×100 mL)
5. 5
   تجفيفdried over magnesium sulfate
6. 6
   تركيزconcentrated in vacuo

الإجراء التجريبي

To a -20° C. solution of cycloheptylamine (6.37 mL, 50.0 mmol) and diisopropylethylamine (9.58 mL, 55.0 mmol) in methylene chloride (250 mL) was slowly added bromoacetyl bromide (4.78 mL, 55.0 mmol). The reaction mixture was warmed to room temperature over 20 minutes and stirred for an addition 30 minutes. The reaction mixture was diluted with water (100 mL) and stirred for an additional 30 minutes. The organic layer was separated, washed with water (3×100 mL), dried over magnesium sulfate and concentrated in vacuo to afford a beige solid (10.5 g). The crude material was further purified by silica gel flash column chromatography using hexane-ethyl acetate (1:1) as the eluent to give the purified title compound as a whim solid (9.77 g, 83%).

المصدر