تفاعل #305388

معادلة التفاعل

morpholine

potassium phosphate tribasic monohydrate

4-Bromo-N-(4-chloro-2-[1,2,3]triazolo[4,5-b]pyridin-1-yl-phenyl)-3-fluoro-benzensulfonamide

→

desired product

المردود 44.2%

N-(4-Chloro-2-[1,2,3]triazolo[4,5-b]pyridin-1-yl-phenyl)-3-fluoro-4-morpholin-4-yl-benzenesulfonamide

المردود 44.2%

المذيبات

dimethylformamide

ظروف التفاعل

المعالجة

1. 1
   أخرىThe following day, the reaction mixture was partitioned with a saturated solution of sodium bicarbonate and dichloromethane
2. 2
   استخلاصthe aqueous layer was extracted three times with dichloromethane
3. 3
   تجفيفThe combined organics were subsequently dried over magnesium sulfate
4. 4
   تركيزconcentrated in vacuo
5. 5
   أخرىpurified by reverse phase HPLC

الإجراء التجريبي

4-Bromo-N-(4-chloro-2-[1,2,3]triazolo[4,5-b]pyridin-1-yl-phenyl)-3-fluoro-benzensulfonamide (synthesized according to general procedure G, 180 mg, 0.37 mmol) was dissolved in 3 ml of anhydrous dimethylformamide under an atmosphere of nitrogen. To this mixture was added morpholine (161 mg, 1.85 mmol), 2,2′-bis(diphenylphosphine)-1,1′-binaphthyl (BINAP) (34 mg, 0.055 mmol), potassium phosphate tribasic monohydrate (511 mg, 2.22 mmol), and tris(dibenzylideneacetone) dipalladium(0) (Pd2(dba)3) and the resultant mixture was heated at 80° C. overnight. The following day, the reaction mixture was partitioned with a saturated solution of sodium bicarbonate and dichloromethane and the aqueous layer was extracted three times with dichloromethane. The combined organics were subsequently dried over magnesium sulfate, concentrated in vacuo, and purified by reverse phase HPLC, followed by silica gel chromatography employing ethyl acetate:hexanes (1:1), to afford 80 mg of the desired product as a white powder: MS (ES) M+H expected 489.1, found 489.0.

المصدر