تفاعل #305229

معادلة التفاعل

water

3-[4-(3-isobutyrylaminophenyl)piperidin-1-yl]propylmethanesulfonate

K2CO3

2-methyl-1H-benzimidazole

→

title compound

المردود 51.0%

2-methyl-1-{3-[4-(3-isobutyrylaminophenyl)piperidin-1-yl]propyl}-1H-benzimidazole

المردود 51.0%

المذيبات

N,N-dimethylformamide

ظروف التفاعل

المعالجة

1. 1
   workup.ADDITIONby treating the mixture at 80° C. for 5 hours
2. 2
   استخلاصextracted with ethylacetate (50 ml×2)
3. 3
   غسيلbeing washed with water
4. 4
   تجفيفa sodium hydroxide solution, and then the combined organic layer was dried over anhydrous sodium sulfate
5. 5
   ترشيحfiltered
6. 6
   أخرىThe solvent was removed from the filtrate under a reduced pressure

الإجراء التجريبي

100 mg (0.75 mmol) of 2-methyl-1H-benzimidazole was dissolved in 5 ml of N,N-dimethylformamide, and 286 mg (0.75 mmol) of 3-[4-(3-isobutyrylaminophenyl)piperidin-1-yl]propylmethanesulfonate and 310 mg (2.25 mmol) of K2CO3 were added to the resulting solution, followed by treating the mixture at 80° C. for 5 hours. The reaction mixture was combined with 50 ml of water and extracted with ethylacetate (50 ml×2) being washed with water and a sodium hydroxide solution, and then the combined organic layer was dried over anhydrous sodium sulfate, and filtered. The solvent was removed from the filtrate under a reduced pressure, and the resulting residue was refined by silica gel column chromatography (5% MeOH/CH2Cl2) to obtain 159 mg (yield 51%) of the title compound.

المصدر