تفاعل #3049

معادلة التفاعل

Water

Allyl bromide

2-t-butylphenol

potassium carbonate

→

2-(1,1-dimethylethyl)phenoxypropene

المذيبات

acetone

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةat reflux temperature for 50 hours
2. 2
   أخرىthe resulting layers were separated
3. 3
   استخلاصThe aqueous layer was extracted with 600 ml of diethyl ether
4. 4
   استخلاصextract
5. 5
   تجفيفthe resulting solution was dried over sodium sulfate overnight
6. 6
   أخرىAfter sodium sulfate removal
7. 7
   أخرىthe solvent was evaporated
8. 8
   أخرىto provide

الإجراء التجريبي

Allyl bromide (69.2 ml), 2-t-butylphenol (122.9 ml) and potassium carbonate (121.6 g) were stirred in 265 ml of acetone at reflux temperature for 50 hours and then cooled to 35° C. Water (600 ml) was added and the resulting layers were separated. The aqueous layer was extracted with 600 ml of diethyl ether. The organic layer was combined with the aqueous layer's ether extract and the resulting solution was dried over sodium sulfate overnight. After sodium sulfate removal, the solvent was evaporated to provide, after further workup, 147 g of the subtitled intermediate.

المصدر