تفاعل #304397

معادلة التفاعل

(5-bromo-6-nitro-pyridin-2-yl)-methyl-carbamic acid tert-butyl ester

(5-Bromo-6-nitro-pyridin-2-yl)-methyl-carbamic acid tert-butyl ester

5-ethoxymethoxy-benzofuran-2-boronic acid

5-Ethoxymethoxy-benzofuran-2-boronic acid

→

desired compound ( 13 )

المردود 90.2%

[5-(5-Ethoxymethoxy-benzofuran-2-yl)-6-nitro-pyridin-2-yl]-methyl-carbamic acid tert-butyl ester

المردود 90.2%

ظروف التفاعل

المعالجة

1. 1
   أخرىwas prepared
2. 2
   أخرىfollowed by purification of the crude product by flash column chromatography
3. 3
   أخرىEvaporation of solvent

الإجراء التجريبي

By following the same procedure as described in Example 1 (step d), was prepared using (5-bromo-6-nitro-pyridin-2-yl)-methyl-carbamic acid tert-butyl ester (12) (100 mg, 0.30 mmol) and 5-ethoxymethoxy-benzofuran-2-boronic acid (4) (92.5 mg, 0.39 mmol). Work-up as described in example 1d, followed by purification of the crude product by flash column chromatography using 10-25% ethyl acetate in hexane. Evaporation of solvent afforded 120 mg of the desired compound (13) as yellowish solid.

المصدر