تفاعل #303544

معادلة التفاعل

Hydrogen chloride

1-[4-(2,2-dimethylpropyl)-1-trityl-1H-imidazol-2-yl]-2-[4-(1-methyl-1H-pyrazol-4-yl)phenyl]propan-2-ol

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title compound

1-[4-(2,2-dimethylpropyl)-1H-imidazol-2-yl]-2-[4-(1-methyl-1H-pyrazol-4-yl)phenyl]propan-2-ol

المذيبات

methanol

ظروف التفاعل

المعالجة

1. 1
   أخرىvolatiles were removed
2. 2
   أخرىThe residue was partitioned between diethyl ether and 1 N hydrochloric acid
3. 3
   غسيلThe aqueous phase was washed with diethyl ether
4. 4
   استخلاصextracted with ethyl acetate
5. 5
   غسيلThe combined organic extracts were washed with brine
6. 6
   تجفيفdried (sodium sulfate)
7. 7
   تركيزconcentrated in vacuo

الإجراء التجريبي

Hydrogen chloride (4 M in 1,4-dioxane) (5.25 mL, 21 mmol) was added to an ambient temperature solution of 1-[4-(2,2-dimethylpropyl)-1-trityl-1H-imidazol-2-yl]-2-[4-(1-methyl-1H-pyrazol-4-yl)phenyl]propan-2-ol (250 mg, 0.42 mmol) in methanol (10 mL). After stirring at 70° C. for 1 h, volatiles were removed. The residue was partitioned between diethyl ether and 1 N hydrochloric acid. The aqueous phase was washed with diethyl ether, basified with 2.5 N aqueous sodium hydroxide and extracted with ethyl acetate. The combined organic extracts were washed with brine, dried (sodium sulfate) and concentrated in vacuo to afford the title compound. (M+H) found 339.

المصدر