تفاعل #303529

معادلة التفاعل

Methanol

2-Methyl-2-butanol

vinylidene chloride

sulfuric acid

ether

→

methyl 3,3-dimethylpentanoate

ظروف التفاعل

المعالجة

1. 1
   أخرىfor 15 minutes
2. 2
   درجة الحرارةthe reaction mixture was cooled
3. 3
   غسيلThe ethereal layer was washed with 1 N aqueous sodium hydroxide and brine
4. 4
   تجفيفdried (magnesium sulfate)
5. 5
   ترشيحfiltered
6. 6
   تركيزconcentrated in vacuo

الإجراء التجريبي

2-Methyl-2-butanol (480 mL, 4.4 mol) and vinylidene chloride (508 mL, 5.2 mol) were added to sulfuric acid (2 L) at 10° C. Methanol (1750 mL) was added slowly, and the reaction mixture reached 60 C for 15 minutes due to exotherm. After 30 min, the reaction mixture was cooled and poured into a stirred mixture of ether and ice water. The ethereal layer was washed with 1 N aqueous sodium hydroxide and brine, dried (magnesium sulfate), filtered, and concentrated in vacuo to afford methyl 3,3-dimethylpentanoate which was used in the subsequent step without further purification.

المصدر