تفاعل #302862

معادلة التفاعل

dipalmitoylglycerol succinate

carbonyldiimidazole

histamine

→

histamine dipalmitoylglycerol succinate

المذيبات

DMF

DMF

ظروف التفاعل

المعالجة

1. 1
   workup.STIRRINGThe mixture is stirred overnight
2. 2
   تركيزconcentrated thoroughly in vacuum
3. 3
   أخرىThe residue is purified

الإجراء التجريبي

1.7 g of dipalmitoylglycerol succinate is dissolved in 20 ml of DMF at room temperature. The solution is added with 400 mg of carbonyldiimidazole dissolved in 20 ml of DMF. The mixture is allowed to stir for 1 hour and subsequently added with 300 mg of histamine. The mixture is stirred overnight and concentrated thoroughly in vacuum. The residue is purified using column chromatography on silica gel 60, with chloroform/methanol 10:1 being used as eluant.

المصدر