تفاعل #2984

معادلة التفاعل

KCN

3-(7-methoxy-1-naphthyl)propyl mesylate

3-(7-METHOXY-1-NAPHTHYL)PROPYL MESYLATE

→

4-(7-METHOXY-1-NAPHTHYL)BUTYRONITRILE

المذيبات

DMSO

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةto reflux for 2 h
2. 2
   درجة الحرارةto cool
3. 3
   استخلاصThe resulting mixture is extracted with ether
4. 4
   غسيلThe organic phase is washed with water
5. 5
   تجفيفdried over CaCl2
6. 6
   أخرىevaporated
7. 7
   أخرىThe product obtained
8. 8
   أخرىis recrystallized

الإجراء التجريبي

In a 100-cm3 flask, the 3-(7-methoxy-1-naphthyl)propyl mesylate obtained in stage D is dissolved in DMSO. KCN is added and the mixture is brought to reflux for 2 h. It is allowed to cool. It is poured into a water/ice mixture. The resulting mixture is extracted with ether. The organic phase is washed with water, dried over CaCl2 and evaporated. The product obtained is recrystallized.

المصدر