تفاعل #2955

معادلة التفاعل

(±)-trans-2-ethyl-4a-(3-methoxyphenyl)-6-oxo-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline hydrochloride

hydroxylamine hydrochloride

→

title compound

المردود 96.6%

(±)-trans-2-Ethyl-6-hydroxyimino-4a-(3-methoxyphenyl)-1,2,3,4,4a,5,6,7,8, 8a-decahydroisoquinoline

المردود 96.6%

المذيبات

MeOH

ظروف التفاعل

المعالجة

1. 1
   ترشيحThe precipitate was filtered
2. 2
   أخرىthe solvent was removed in vacuo
3. 3
   استخلاصthe aqueous layer was extracted with CH2Cl2
4. 4
   أخرىThe organic layer was dried
5. 5
   أخرىthe solvent removed in vacuo

الإجراء التجريبي

0.5 g (1.54 mmol) of (±)-trans-2-ethyl-4a-(3-methoxyphenyl)-6-oxo-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline hydrochloride, 0.456 g (6.56 mmol) of hydroxylamine hydrochloride and 0.64 g of KHCO3 in 10 ml of MeOH were refluxed for 45 min. The precipitate was filtered, the solvent was removed in vacuo and the residue taken up in H2O. The pH was adjusted to 8 with conc. NH4OH, the aqueous layer was extracted with CH2Cl2. The organic layer was dried, the solvent removed in vacuo, obtaining 0.45 g of the title compound which was used as such in the subsequent step.

المصدر