تفاعل #2945

معادلة التفاعل

diketene acetone

pyrrolidine

→

title compound

المردود 97.9%

1-(3-Oxobutyryl)pyrrolidine

المردود 97.9%

المذيبات

toluene

ظروف التفاعل

المعالجة

1. 1
   أخرىas described in preparation 7
2. 2
   أخرىThe solvent was removed in vacuo
3. 3
   أخرىthe residue was purified by chromatography on silica gel (EtOAc/MeOH 0%→1%)

الإجراء التجريبي

9 ml (0.05 mol) of diketene-acetone adduct and a solution of 4.2 ml (0.05 mol) of pyrrolidine in 20 ml of toluene were treated as described in preparation 7. The solvent was removed in vacuo and the residue was purified by chromatography on silica gel (EtOAc/MeOH 0%→1%) yielding 7.6 g of the title compound as a dark oil.

المصدر