تفاعل #2926

معادلة التفاعل

hydrochloric acid

Tetrabutylammonium fluoride

2,4-dimethyl-5-oxazolyl 3-furyl ketone

(trifluoromethyl) trimethylsilane

sodium hydrogen carbonate

→

1-(2,4-Dimethyl-5-oxazolyl)-1-(3-furyl)-2,2,2-trifluoroethanol

المذيبات

tetrahydrofuran

ظروف التفاعل

المعالجة

1. 1
   استخلاصextracted with dichloromethane
2. 2
   أخرىThe material thus obtained
3. 3
   أخرىwas purified by flash chromatography and recrystallisation from diethyl ether

الإجراء التجريبي

Tetrabutylammonium fluoride (250 mg) was added to a stirred solution of 2,4-dimethyl-5-oxazolyl 3-furyl ketone (1.7 g) and (trifluoromethyl) trimethylsilane (1.9 g) in dry tetrahydrofuran (30 ml) at -10° C. The mixture was allowed to warm to room temperature. After 45 minutes 6M hydrochloric acid (30 ml) was added. After 1 hour the mixture was basified by the addition of saturated aqueous sodium hydrogen carbonate and then extracted with dichloromethane. The material thus obtained was purified by flash chromatography and recrystallisation from diethyl ether.

المصدر