تفاعل #2919

معادلة التفاعل

5-Acetyl-2,4-dimethylthiazole

3-lithiopyridine

sodium hydrogen carbonate

→

title compound

1-(2,4-Dimethyl-5-thiazolyl)-1-(3-pyridyl)ethanol

المذيبات

diethylether

diethylether

ظروف التفاعل

المعالجة

1. 1
   workup.WAITAfter a further 1 hour
2. 2
   أخرىthe organic layer was separated
3. 3
   استخلاصThe aqueous layer was extracted with diethylether
4. 4
   أخرىThe material obtained from the combined organic layers
5. 5
   أخرىwas purified by flash chromatography

الإجراء التجريبي

5-Acetyl-2,4-dimethylthiazole (2.5 g) in dry diethylether (10 ml) was added dropwise to a stirred solution of 3-lithiopyridine (from 3.5 g 3-bromopyridine) in diethylether at -70° C. After 3 hours the mixture was allowed to warm to room temperature. After a further 1 hour, aqueous sodium hydrogen carbonate was added and the organic layer was separated. The aqueous layer was extracted with diethylether. The material obtained from the combined organic layers was purified by flash chromatography to give the title compound, m.p. 107.5°-109° C.

المصدر