تفاعل #2901

معادلة التفاعل

ethanol

3-Furyl-4-methyl-5-oxazolyl ketone

methyllithium

sodium chloride

→

1-(3-furyl)-1-(4-methyl-5-oxazolyl)ethanol

المذيبات

diethylether

ظروف التفاعل

المعالجة

1. 1
   استخلاصextracted with dichloromethane
2. 2
   أخرىChromatography and crystallisation

الإجراء التجريبي

3-Furyl-4-methyl-5-oxazolyl ketone (1 g) in dry diethylether (15 ml) at -70° C. under a nitrogen atmosphere was treated dropwise with methyllithium (1.5M solution in diethylether, 4.1 ml). After 45 minutes the reaction mixture was allowed to warm to room temperature and ethanol (2 ml) was added. The mixture was poured into saturated aqueous sodium chloride and extracted with dichloromethane. Chromatography and crystallisation then gave 1-(3-furyl)-1-(4-methyl-5-oxazolyl)ethanol identical to the material obtained in (a) above.

المصدر