تفاعل #2900

معادلة التفاعل

4-Methyl-5-thiazolecarbaldehyde

aluminium isopropoxide

sodium hydride

→

title compound

5-Methoxymethyl-4-methylthiazole

المذيبات

dimethoxyethane

iodomethane

2-propanol

ظروف التفاعل

المعالجة

1. 1
   workup.ADDITIONwas added
2. 2
   workup.DISTILLATIONDistillation

الإجراء التجريبي

4-Methyl-5-thiazolecarbaldehyde (J. Amer. Chem. Soc., 1982, 104, 4934-4943) was reduced using aluminium isopropoxide in 2-propanol. The resulting alcohol was treated with sodium hydride in dimethoxyethane and iodomethane was added. Distillation gave the title compound.

المصدر