تفاعل #2893

معادلة التفاعل

N-Methoxy-N-methyl-4-methyl-5-oxazolecarboxamide

ethylmagnesium bromide

sodium hydrogen carbonate

→

4-Methyl-5-propionyloxazole

المذيبات

tetrahydrofuran

ظروف التفاعل

المعالجة

1. 1
   أخرىthe organic layer was separated
2. 2
   استخلاصthe aqueous layer was extracted with diethylether
3. 3
   أخرىThe material thus obtained
4. 4
   أخرىwas purified by flash chromatography
5. 5
   أخرىto yield a pale yellow liquid which
6. 6
   درجة الحرارةon cooling

الإجراء التجريبي

N-Methoxy-N-methyl-4-methyl-5-oxazolecarboxamide (5 g) in dry tetrahydrofuran at -40° C. was stirred under a nitrogen atmosphere and ethylmagnesium bromide (1M solution in tetrahydrofuran, 35 ml) was added dropwise. After 30 minutes the mixture was allowed to warm to room temperature and then stirred for a further 1 hour. Aqueous sodium hydrogen carbonate was added, the organic layer was separated and the aqueous layer was extracted with diethylether. The material thus obtained was purified by flash chromatography to yield a pale yellow liquid which solidified on cooling.

المصدر