تفاعل #2892

معادلة التفاعل

sodium hydroxide

3-Chloropentane-2,4-dione

propionamide

propionic acid

→

5-Acetyl-2-ethyl-4-methyloxazole

ظروف التفاعل

المعالجة

1. 1
   استخلاصextracted with dichloromethane
2. 2
   غسيلThe combined extracts were washed with brine
3. 3
   أخرىdried
4. 4
   أخرىthe solvent removed
5. 5
   أخرىto leave a brown oil which
6. 6
   workup.DISTILLATIONwas purified by vacuum distillation, b.p. 70° C. at 2 mbar

الإجراء التجريبي

3-Chloropentane-2,4-dione (46.5 g), propionamide (50 g) and propionic acid (151 g) were heated at 145° C. for 5 hours. The mixture was cooled to room temperature, then basified to pH 10 using 10M aqueous sodium hydroxide, and extracted with dichloromethane. The combined extracts were washed with brine, dried and the solvent removed to leave a brown oil which was purified by vacuum distillation, b.p. 70° C. at 2 mbar.

المصدر