تفاعل #2891

معادلة التفاعل

sodium chloride

n-butyllithium

3-Bromofuran

N-methoxy-N-methyl-4-methyl-5-oxazolecarboxamide

→

title compound

3-Furyl 4-Methyl-5-oxazolyl Ketone

المذيبات

Ethanol

diethylether

diethylether

ظروف التفاعل

المعالجة

1. 1
   workup.WAITAfter a further 30 minutes the mixture was allowed
2. 2
   درجة الحرارةto warm to room temperature
3. 3
   استخلاصThe mixture was extracted with dichloromethane
4. 4
   أخرىthe material thus obtained
5. 5
   أخرىwas purified by flash chromatography

الإجراء التجريبي

3-Bromofuran (2.5 g) in dry diethylether was stirred and cooled to -70° C. under an atmosphere of dry nitrogen and n-butyllithium (2.5M solution in hexane, 6.8 ml) was added dropwise. After 30 minutes, N-methoxy-N-methyl-4-methyl-5-oxazolecarboxamide (2.89 g) in dry diethylether was added dropwise. After a further 30 minutes the mixture was allowed to warm to room temperature. Ethanol (5 ml) was added followed by saturated aqueous sodium chloride. The mixture was extracted with dichloromethane and the material thus obtained was purified by flash chromatography to give the title compound. M.p. 82°-83.5° C.

المصدر