تفاعل #2886

معادلة التفاعل

4,5-dichloro-2-methyl-1-[4-(4-oxo-1-piperidyl)butyl]-1H-imidazole

MgCl2

4-methylphenylmagnesium bromide

ammonium chloride

→

4,5-dichloro-1-{4-[4-hydroxy-4-(4-methylphenyl)-1-piperidyl]butyl}-2-methyl-1H-imidazole

المذيبات

tetrahydrofuran

THF

ظروف التفاعل

المعالجة

1. 1
   workup.STIRRINGThe resulting suspension is stirred for 15 minutes at -40° C. and for 3 hours at room temperature
2. 2
   أخرىthe tetrahydrofuran is evaporated
3. 3
   استخلاصThe resulting aqueous phase is extracted with chloroform
4. 4
   غسيلThe chloroform phase is washed with water
5. 5
   تجفيفdried with anhydrous sodium sulfate
6. 6
   أخرىevaporated to dryness
7. 7
   أخرىa crude product being obtained which
8. 8
   أخرىis purified by chromatography on silica gel

الإجراء التجريبي

A solution of 1.0 g (3.3 mmol) of 4,5-dichloro-2-methyl-1-[4-(4-oxo-1-piperidyl)butyl]-1H-imidazole in 10 ml of anhydrous tetrahydrofuran is added to a suspension of 1.08 g (11.4 mmol) of MgCl2 in 15 ml of anhydrous THF at -40° C. and under a nitrogen atmosphere. The mixture is stirred for 5 minutes and then, at -40° C., 6.8 ml of a 1.0M solution of 4-methylphenylmagnesium bromide are added. The resulting suspension is stirred for 15 minutes at -40° C. and for 3 hours at room temperature. An aqueous ammonium chloride solution is then added and the tetrahydrofuran is evaporated. The resulting aqueous phase is extracted with chloroform. The chloroform phase is washed with water, dried with anhydrous sodium sulfate and evaporated to dryness, a crude product being obtained which is purified by chromatography on silica gel, giving 1.02 g (2.6 mmol) of 4,5-dichloro-1-{4-[4-hydroxy-4-(4-methylphenyl)-1-piperidyl]butyl}-2-methyl-1H-imidazole.

المصدر