تفاعل #2876

معادلة التفاعل

N-bromosuccinimide

5-bromo-2-fluoro-benzyl alcohol

triphenyl phosphine

→

title compound

المردود 96.7%

5-Bromo-2-fluoro-benzyl bromide

المردود 96.7%

المذيبات

THF

ظروف التفاعل

المعالجة

1. 1
   أخرىThe ice bath is removed
2. 2
   أخرىThe crude product is purified by column chromatography
3. 3
   غسيلeluting with 5% EtOAc/hexanes

الإجراء التجريبي

To a solution of 5-bromo-2-fluoro-benzyl alcohol (3.10 g, 15.1 mmol) in 30 mL of THF at 10° C. is added triphenyl phosphine (4.10 g, 15.6 mmol) followed by N-bromosuccinimide (2.67 g, 15.0 mmol). The ice bath is removed and the resulting solution is stirred for 20 min at room temperature. The crude product is purified by column chromatography eluting with 5% EtOAc/hexanes to give the title compound (3.90 g, 14.5 mmol).

المصدر