تفاعل #2863

معادلة التفاعل

5-chlorothieno[3,2-b]pyridine-2-sulfonyl chloride

4-(3-(S)-amino-2-oxo-pyrrolidin-1-ylmethyl)-thiophene-2carbonitrile hydrochloride

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title compound

5-Chlorothieno[3,2-b]pyridine-2-sulfonic acid [1-(5-cyanothiophen-3-ylmethyl)-2-oxo-pyrrolidin-3-(S)-yl]-amide

ظروف التفاعل

المعالجة

1. 1
   أخرىThe product is triturated with Et2O/CH2Cl2 /hexanes
2. 2
   أخرىto give a white solid

الإجراء التجريبي

The title compound is prepared from 4-(3-(S)-amino-2-oxo-pyrrolidin-1-ylmethyl)-thiophene-2carbonitrile hydrochloride as described in EXAMPLE 1, Part E using 5-chlorothieno[3,2-b]pyridine-2-sulfonyl chloride in place of benzo[b]thiophene-2-sulfonyl chloride. The product is triturated with Et2O/CH2Cl2 /hexanes to give a white solid.

المصدر