تفاعل #2693

معادلة التفاعل

n-butyllithium

2,2,6,6-Tetramethylbenzo[1,2-d:4,5-d']-bis(1,3)dioxole

water

4-methoxycarbonyl-(2,2,6,6-tetramethylbenzo[1,2-d:4,5-d']-bis(1,3)dithiole)

→

Bis-(2,2,6,6-tetramethylbenzo[1,2-d:4,5-d']-bis(1,3)dioxol-4-yl)-mono-(2,2,6,6-tetramethylbenzo[1,2-d:4,5-d']-bis(1,3)dithiole-4-yl)methanol

المذيبات

ether

ether

ظروف التفاعل

المعالجة

1. 1
   workup.ADDITIONfilled
2. 2
   أخرىreaction vessel
3. 3
   درجة الحرارةthe mixture was cooled to 0° C.
4. 4
   workup.STIRRINGThe reaction was stirred at ambient temperature overnight
5. 5
   أخرىThe organic layer was separated
6. 6
   غسيلthe aqueous phase was washed once more with ether
7. 7
   تجفيفThe organic phase was dried (Na2SO4)
8. 8
   أخرىevaporated
9. 9
   أخرىto give a semisolid residue
10. 10
    أخرىThe product was recrystallized from acetonitrile

الإجراء التجريبي

2,2,6,6-Tetramethylbenzo[1,2-d:4,5-d']-bis(1,3)dioxole (5.15 g, 23.2 mmol) was dissolved in dry ether (40.0 mL) in a dried, argon filled reaction vessel. The solution was cooled to 0° C. and n-butyllithium (9.29 mL, 2.5M in hexane) was added. After stirring for 15 min at ambient temperature, the mixture was cooled to 0° C. and 4-methoxycarbonyl-(2,2,6,6-tetramethylbenzo[1,2-d:4,5-d']-bis(1,3)dithiole)(4.0 g, 11.6 mmol) was added portionwise. The reaction was stirred at ambient temperature overnight. The voluminous precipitate was dissolved by addition of water (70 mL) and ether (50 mL). The organic layer was separated and the aqueous phase was washed once more with ether. The organic phase was dried (Na2SO4) and evaporated to give a semisolid residue. The product was recrystallized from acetonitrile. Yield of pure product was 5.26 g (60%).

المصدر