تفاعل #2609

معادلة التفاعل

ammonium chloride

sodium hydride

4-Acetylamino-N-{2-[4-(4-fluorobenzoyl)piperidino]ethyl}-N-(4-methoxyphenyl)benzamide

methyl iodide

→

title compound

المردود 80.4%

4-(N-Methylacetylamino)-N-{2-[4-(4-fluorobenzoyl)piperidino]ethyl}-N-(4-methoxyphenyl)benzamide

المردود 80.4%

المذيبات

THF

ظروف التفاعل

المعالجة

1. 1
   أخرىat room temperature
2. 2
   استخلاصextracted with ethyl acetate
3. 3
   غسيلThe resulting organic layer was washed with water and saturated brine
4. 4
   تجفيفdried on anhydrous sodium sulfate
5. 5
   أخرىThereafter, the solvent was removed by evaporation
6. 6
   أخرىthe resulting residue was recrystallized from methanol-ether

الإجراء التجريبي

4-Acetylamino-N-{2-[4-(4-fluorobenzoyl)piperidino]ethyl}-N-(4-methoxyphenyl)benzamide (155.0 mg, 0.30 mmol) was dissolved in THF (3.0 ml) to which were subsequently added 60% sodium hydride {28.0 mg, 0.70 mmol) and methyl iodide (0.060 ml, 1.00 mmol) at room temperature, followed by 2 hours of stirring. The reaction solution was mixed with saturated ammonium chloride aqueous solution and extracted with ethyl acetate. The resulting organic layer was washed with water and saturated brine, and dried on anhydrous sodium sulfate. Thereafter, the solvent was removed by evaporation, and the resulting residue was recrystallized from methanol-ether to obtain 128.0 mg (80.4%) of the title compound in a colorless powder form.

المصدر