تفاعل #2566

معادلة التفاعل

N-{2-[4-(4-Fluorobenzoyl)piperidino]ethyl}-4-tetrahydropyranyloxymethyl-N-(2-methoxyphenyl)benzene sulfonamide

p-toluenesulfonic acid monohydrate

sodium bicarbonate

→

title compound

المردود 100.1%

N-{2-[4-(4-fluorobenzoyl)piperidino]ethyl}-4-hydroxymethyl-N-(2-methoxyphenyl)benzene sulfonamide

المردود 100.1%

المذيبات

methanol

methanol

ظروف التفاعل

المعالجة

1. 1
   أخرىat room temperature
2. 2
   أخرىwas removed by evaporation
3. 3
   أخرىthe resulting reaction solution
4. 4
   استخلاصextracted with ethyl acetate
5. 5
   غسيلwashed with water and saturated brine
6. 6
   استخلاصThe water layer was extracted with ethyl acetate
7. 7
   غسيلwashed with water and saturated brine
8. 8
   تجفيفdried on anhydrous sodium sulfate
9. 9
   أخرىThereafter, the solvent was removed by evaporation
10. 10
    أخرىthe resulting residue was purified by a silica gel column chromatography (ethyl acetate)

الإجراء التجريبي

N-{2-[4-(4-Fluorobenzoyl)piperidino]ethyl}-4-tetrahydropyranyloxymethyl-N-(2-methoxyphenyl)benzene sulfonamide (101 mg, 0.165 mmol) was dissolved in methanol (5 ml) to which was subsequently added p-toluenesulfonic acid monohydrate (35 mg, 0.18 mmol) at room temperature. After 2 hour of stirring at the same temperature, methanol was removed by evaporation, and the resulting reaction solution was mixed with saturated sodium bicarbonate aqueous solution (5 ml), extracted with ethyl acetate, and washed with water and saturated brine. The water layer was extracted with ethyl acetate, and washed with water and saturated brine, and the organic layers were combined and dried on anhydrous sodium sulfate. Thereafter, the solvent was removed by evaporation, and the resulting residue was purified by a silica gel column chromatography (ethyl acetate) to obtain 87 mg (100%) of the title compound in the form of colorless oil.

المصدر