تفاعل #2560

معادلة التفاعل

N-(2-hydroxyethyl)-3-methoxy-N-(2-methoxyphenyl)benzamide

triethylamine

→

title compound

المردود 65.6%

N-Formylmethyl-3-methoxy-N-(2-methoxyphenyl)benzamide

المردود 65.6%

المذيبات

DMSO

DMSO

ظروف التفاعل

المعالجة

1. 1
   أخرىat room temperature
2. 2
   استخلاصextracted with ethyl acetate
3. 3
   غسيلwashed with water and saturated brine
4. 4
   تجفيفThe resulting organic layer was dried on anhydrous magnesium sulfate
5. 5
   أخرىthe solvent was removed by evaporation

الإجراء التجريبي

In an atmosphere of argon, N-(2-hydroxyethyl)-3-methoxy-N-(2-methoxyphenyl)benzamide (339 mg, 1.12 mmol) was dissolved in DMSO (4 ml) to which were subsequently added dropwise triethylamine (0.724 ml, 5.20 mmol) and a DMSO solution (8 ml) of a sulfur trioxide-pyridine complex (844 mg, 5.20 mmol) at room temperature. After 20 minutes of stirring at the same temperature, this was mixed with ice water (40 ml) and extracted with ethyl acetate, and then washed with water and saturated brine. The resulting organic layer was dried on anhydrous magnesium sulfate, and the solvent was removed by evaporation to obtain 220 mg (65.6%) of the title compound the form of light yellow solid.

المصدر